Pao Pereira is an indigenous tree from the Amazon rain-forest. It is used as an alternative therapy for many cancers. It has been known to be used as a synergistic adjunct therapy; alongside chemo and radiotherapy in the many forms of cancer. It is known to effectively suppress the proliferation of HIV, herpes viruses, and leukemia cells
|Botanical Name||Geissospermum vellosii Fr., Geissospermum leave, Tabernaemontana laevis|
Pereiroá, Ubá-açú, Triguaaba, Camará-de-bilro
|Origin||Brazil, Amazon Rain Forest|
|Price||$15.95||Add to cart|
Animal studies suggest that pao pereira has antimalarial and anticancer effects. Human studies have not been conducted.
Pao pereira is a tree native to the northern part of South America. Preparations made from the stem bark are used in folk medicine to treat malaria, digestive disorders, constipation, fever, liver pain, and cancer, and as sexual stimulants. Laboratory and animal studies show that the bark extracts have antimalarial and pain-relieving properties, may help improve cognition, and may also have anticancer effects.
Studies done in vitro and in animal models using the bark extracts indicate antimalarial (1), antinociceptive (2) (11), and anti-inflammatory (11) effects, as well as anticholinesterase activity resulting in reversal of cognitive defects (3). This property is being explored as a potential treatment for Alzheimer’s disease (4). Flavopereirine derived from pao pereira demonstrated activity against leishmaniasis in vitro (13).
The anticancer potential of pao pereira has also been investigated. In preclinical studies, the bark extracts demonstrated antitumor activity and enhanced carboplatin effects in ovarian cancer cells (5). It also suppressed the growth of prostate cancer (6) (7) and pancreatic cancer cells along with potentiating gemcitabine effects (8), and inhibited pancreatic cancer stem-like cells (12). Clinical trials have not yet been conducted.
Pao pereira is marketed in supplemental form as an alternative anticancer treatment, but safety and efficacy has not been determined.
Mechanism of Action
Anticancer effects are attributed to various mechanisms. One study showed that pao pereira induces apoptosis in pancreatic cells in vitro and in vivo via cleavage of caspases 3 and 8 and PARP, associated with DNA damage and cell cycle inhibition (8). In the prostate cancer cell line LNCaP, reduced tumor cell growth and induced apoptosis by pao pereira extract may occur via beta-carboline alkaloids that upregulate DNA repair response genes as well as genes involved in the apoptotic pathway (6). Another study suggests the extract induces cell growth arrest and apoptosis in LNCaP cells partially via inhibition of nuclear factor kappa B (NFκB) activation, which is responsible for cell survival (7).